The purpose of this Funding Opportunity (NOFO) is to solicit grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including medications and medical devices to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical adoption. This NOFO will utilize the UG3/UH3 activity code.

PAR-25-446: Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)

Part 1. Overview Information

Participating Organization(s) National Institutes of Health (NIH)

Components of Participating Organizations National Institute on Drug Abuse (NIDA)

Funding Opportunity Title Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)

Activity Code UG3/UH3 Exploratory/Developmental Phased Award Cooperative Agreement

Announcement Type Reissue of PAR-25-329

Related Notices

• November 24, 2025 - Notice to Expire PAR-25-023, "Device Based Treatments for Substance Use Disorders (UG3/UH3 Clinical Trial Optional)". See Notice NOT-DA-25-042.
• April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025. See Notice NOT-OD-24-084.
• August 31, 2022 - Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
• August 5, 2022 - Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Funding Opportunity Number (FON) PAR-25-446

Companion Funding Opportunity None

Number of Applications See Section III. 3. Additional Information on Eligibility

Assistance Listing Number(s) 93.279

Funding Opportunity Purpose The purpose of this notice of funding opportunity (NOFO) is to seek grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including interventions to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical adoption. This NOFO will utilize the UG3/UH3 activity code.

Funding Opportunity Goal(s)

• To support basic, clinical, translational, and implementation research in the field of substance use.
• To develop new knowledge and approaches for the prevention, diagnosis, and treatment of drug use, misuse, and addiction, drug overdose, and related health outcomes, including HIV/AIDS.

Key Dates

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