PAR-25-207
Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required)
Summary
PAR-25-207: Effectiveness Trials for Post-Acute Mental Health Interventions
Research Focus
NIMH seeks effectiveness trials testing therapeutic and service delivery interventions for post-acute phase management of mental health conditions in youth, adults, and older adults. The post-acute phase encompasses continuation and maintenance treatment following acute episode management—consolidating treatment gains, managing residual symptoms, preventing relapse, and promoting long-term adherence and service engagement. Trials must be statistically powered to provide definitive effectiveness evidence and explicitly examine mechanisms of action, mediators, and predictors/moderators of intervention response. Research should address chronic or relapsing conditions (anxiety disorders, mood disorders, ADHD, psychotic disorders) where incomplete clinical response, symptom dissipation, and relapse risk remain significant challenges. Priority areas include pharmacological, psychosocial, and neuromodulation continuation/maintenance strategies; care transition facilitation; technology-assisted monitoring and adherence interventions; preventive approaches for gateway conditions; and population-level strategies using electronic health records (EHRs). Trials reducing disparities in post-acute outcomes for underserved populations (racial/ethnic minorities, rural residents, language/culturally isolated groups) are strongly encouraged.
At a Glance
- Who can apply: Not stated (see NIH R01 eligibility guidelines)
- Funding & project length: Not stated in overview
- Award mechanism: R01 Research Project Grant (clinical trial required)
- Key dates: Applications due February 5, 2025 (earliest); subsequent rounds June 5, 2025, October 5, 2025, and beyond through January 8, 2028
- Best fit for: Clinical researchers in psychiatry, psychology, behavioral health, and health services studying post-acute mental health interventions; populations with chronic/relapsing mental illness; mixed-methods designs incorporating mechanism measurement
Key Facts
Deadline
Fri, January 7, 2028
Posted
Thu, October 31, 2024
Keywords
Research Areas
Gotchas (1)
Applicants must explicitly measure and test hypothesized change mechanisms/targets in the effectiveness trial context, not just measure outcomes. This is a required scientific component beyond standar
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Source Text
“Consistent with the NIMH experimental therapeutics approach, this NOFO is intended to support effectiveness trials that not only test the intervention effects on outcomes of interest but also explicitly inform understanding regarding whether the intervention engages associated change mechanisms that were previously identified under more controlled efficacy conditions, thereby reconfirming the intervention targets and testing whether previously identified change mechanisms are operative in the ef”