The purpose of the NIH Mentored Research Scientist Development Award (K01) is to provide support and protected time (three to five years) for an intensive, supervised career development experience in the biomedical, behavioral, or clinical sciences leading to research independence. Although all of the participating NIH Institutes and Centers (ICs) use this support mechanism to support career development experiences that lead to research independence, some ICs use the K01 award for individuals who propose to train in a new field or for individuals who have had a hiatus in their research career because of illness or pressing family circumstances. Other ICs use the K01 to support career development in specific fields. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or a separate ancillary clinical trial. Applicants to this FOA are permitted to propose research experience in a clinical trial led by a mentor or co-mentor. Applicants proposing a clinical trial or an ancillary clinical trial as lead investigator, should apply to the companion NOFO.

PA-24-176: Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed)

March 31, 2025

This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.

Department of Health and Human Services

Part 1. Overview Information

Participating Organization(s) National Institutes of Health (NIH)

Components of Participating Organizations

• NATIONAL INSTITUTES OF HEALTH (NIH)
• National Heart, Lung, and Blood Institute (NHLBI)
• National Human Genome Research Institute (NHGRI)
• National Institute on Aging (NIA)
• National Institute on Alcohol Abuse and Alcoholism (NIAAA)
• National Institute of Allergy and Infectious Diseases (NIAID)
• National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
• National Institute of Biomedical Imaging and Bioengineering (NIBIB)
• Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
• National Institute on Deafness and Other Communication Disorders (NIDCD)
• National Institute of Dental and Craniofacial Research (NIDCR)
• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• National Institute on Drug Abuse (NIDA)
• National Institute of Environmental Health Sciences (NIEHS)
• National Institute of Mental Health (NIMH)
• National Institute of Nursing Research (NINR)
• National Institute on Minority Health and Health Disparities (NIMHD)
• National Library of Medicine (NLM)
• National Center for Complementary and Integrative Health (NCCIH)
• National Cancer Institute (NCI)

All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers:

• Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (ORIP)
• Office of Research on Women's Health (ORWH)
• Office of Data Science Strategy (ODSS)

Special Note: Not all NIH Institutes and Centers participate in Parent Announcements. Applicants should carefully note which ICs participate in this announcement and view their respective areas of research interest and requirements at the Table of IC-Specific Information, Requirements and Staff Contacts website. ICs that do not participate in this announcement will not consider applications for funding. Consultation with NIH staff before submitting an application is strongly encouraged.

Funding Opportunity Title Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed)

Activity Code K01

Research Scientist Development Award - Research & Training

Announcement Type Reissue of PA-20-190

Related Notices See Notices of Special Interest associated with this funding opportunity

• November 24, 2025 - Notice of Rescheduled NIDCR Pre-Application and Technical Assistance Webinars on Applying for Fellowship (F) Awards and Career Development (K) Awards. See Notice NOT-DE-26-013.
• September 25, 2025 - Notice of NIDCR Pre-Application and Technical Assistance Webinars on Applying for Fellowship (F) Awards and Career Development (K) Awards. See Notice NOT-DE-26-012.
• July 9, 2025 - Revised NIAID Policy Defining the Institute’s Use of the Mentored Research Scientist Development (K01) Award. See Notice NOT-AI-25-038
• March 31, 2025 - This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.
• April 04, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025. See Notice NOT-OD-24-084
• November 12, 2024 - Notice of Change in Eligibility Requirements for the NIDDK K01- PA-24-175 and PA-24-176. See Notice NOT-DK-25-001.
• June 4, 2024 - Guidance Regarding Reduction of Effort for NIMHD Individual Mentored K Awards. See Notice NOT-MD-24-017
• May 30, 2024 - Notice to Alert the Public of NIDA's Career Development Award Salary Limits. See Notice NOT-DA-24-032
• May 7, 2024 - Notice of Information: NIAID to Increase K99, K25, and K01 Salary and Research Support and R00 Years of Support. See Notice NOT-AI-24-038
• August 31, 2022 - Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
• August 5, 2022 - Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Funding Opportunity Number (FON) PA-24-176

Companion Funding Opportunity PA-24-175, K01 Research Scientist Development Award - Research & Training PA-24-177, K01 Research Scientist Development Award - Research & Training

Number of Applications See Section III. 3. Additional Information on Eligibility.

Assistance Listing Number(s) 93.242, 93.113, 93.307, 93.866, 93.273, 93.313, 93.398, 93.351, 93.865, 93.172, 93.279, 93.213, 93.310, 93.173, 93.879, 93.286, 93.361, 93.121, 93.837, 93.838, 93.233, 93.839, 93.840, 93.846, 93.855, 93.847

Funding Opportunity Purpose The purpose of the NIH Mentored Research Scientist Development Award (K01) is to provide support and “protected time” (three to five years) for an intensive, supervised career development experience in the biomedical, behavioral, or clinical sciences leading to research independence. Although all of the participating NIH Institutes and Centers (ICs) use this support mechanism to support career development experiences that lead to research independence, some ICs use the K01 award for individuals who propose to train in a new field or for individuals who have had a hiatus in their research career because of illness or pressing family circumstances. Other ICs use the K01 to support career development in specific fields.

This Notice of Funding Opportunity (NOFO) is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or a separate ancillary clinical trial. Applicants to this NOFO are permitted to propose research experience in a clinical trial led by a mentor or co-mentor. Applicants proposing a clinical trial or an ancillary clinical trial as lead investigator, should apply to the companion NOFO (PA-24-175).

Key Dates

• Posted Date: April 24, 2024
• Open Date (Earliest Submission Date): May 12, 2024
• Letter of Intent Due Date(s): Not Applicable

The following table includes NIH standard due dates marked with an asterisk.

| Application Due Dates | Review and Award Cycles