The purpose of the Mentored Quantitative Research Career Development Award (K25) is to attract to NIH-relevant research those investigators whose quantitative science and engineering research has thus far not been focused primarily on questions of health and disease. The K25 award will provide support and "protected time" for a period of supervised study and research for productive professionals with quantitative (e.g., mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry) and engineering backgrounds to integrate their expertise with NIH-relevant research.This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary clinical trial. Applicants to this FOA are permitted to propose research experience in a clinical trial led by a mentor or co-mentor. Applicants proposing a clinical trial or an ancillary clinical trial as lead investigator, should apply to the companion FOA ().

PA-24-191: Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Not Allowed)

March 31, 2025

This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.

Part 1. Overview Information

Participating Organization(s) National Institutes of Health (NIH)

Components of Participating Organizations

• NATIONAL INSTITUTES OF HEALTH (NIH)
• National Eye Institute (NEI)
• National Heart, Lung, and Blood Institute (NHLBI)
• National Institute on Aging (NIA)
• National Institute on Alcohol Abuse and Alcoholism (NIAAA)
• National Institute of Allergy and Infectious Diseases (NIAID)
• National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
• National Institute of Biomedical Imaging and Bioengineering (NIBIB)
• Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
• National Institute on Deafness and Other Communication Disorders (NIDCD)
• National Institute of Dental and Craniofacial Research (NIDCR)
• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• National Institute on Drug Abuse (NIDA)
• National Institute of Environmental Health Sciences (NIEHS)
• National Institute of General Medical Sciences (NIGMS)
• National Cancer Institute (NCI)
• National Library of Medicine (NLM), November 25, 2024 - Participation added (NOT-LM-24-007)

All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers:

• Office of Research on Women's Health (ORWH)
• Office of Data Science Strategy (ODSS)

Special Note: Not all NIH Institutes and Centers participate in Parent Announcements. Candidates should carefully note which ICs participate in this announcement and view their respective areas of research interest and requirements at the Table of IC-Specific Information, Requirements and Staff Contacts website. ICs that do not participate in this announcement will not consider applications for funding. Consultation with NIH staff before submitting an application is strongly encouraged.

Funding Opportunity Title Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Not Allowed)

Activity Code K25

Mentored Quantitative Research Career Development Award

Announcement Type Reissue of PA-20-199

Related Notices See Notices of Special Interest associated with this funding opportunity

• November 24, 2025 - Notice of Rescheduled NIDCR Pre-Application and Technical Assistance Webinars on Applying for Fellowship (F) Awards and Career Development (K) Awards. See Notice NOT-DE-26-013.
• September 25, 2025 - Notice of NIDCR Pre-Application and Technical Assistance Webinars on Applying for Fellowship (F) Awards and Career Development (K) Awards. See Notice NOT-DE-26-012.
• March 31, 2025 - This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.
• April 04, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025. See Notice NOT-OD-24-084
• November 25, 2024 - Notice of NLM Participation on PA-24-191 "Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Not Allowed)". See Notice NOT-LM-24-007.
• August 30, 2024 - Notice of NHGRI Withdrawal of Participation From PA-24-191 "Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Not Allowed)". See Notice NOT-HG-24-046.
• May 30, 2024 - Notice to Alert the Public of NIDA's Career Development Award Salary Limits. See Notice NOT-DA-24-032.
• May 7, 2024 - Notice of Information: NIAID to Increase K99, K25, and K01 Salary and Research Support and R00 Years of Support. See Notice NOT-AI-24-038.
• August 31, 2022 - Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
• August 5, 2022 - Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Funding Opportunity Number (FON) PA-24-191

Companion Funding Opportunity

• PA-24-190, K25 Mentored Quantitative Research Career Development
• PA-24-192, K25 Mentored Quantitative Research Career Development

Number of Applications See Section III. 3. Additional Information on Eligibility.

Assistance Listing Number(s) 93.846, 93.859, 93.866, 93.121, 93.855, 93.865, 93.847, 93.279, 93.867, 93.113, 93.286, 93.233, 93.837, 93.838, 93.839, 93.840, 93.310, 93.172, 93.398, 93.313, 93.273, 93.173, 93.879

Funding Opportunity Purpose The purpose of the Mentored Quantitative Research Career Development Award (K25) is to attract to NIH-relevant research those investigators whose quantitative science and engineering research has thus far not been focused primarily on questions of health and disease. The K25 award will provide support and "protected time" for a period of supervised study and research for productive professionals with quantitative (e.g., mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry) and engineering backgrounds to integrate their expertise with NIH-relevant research.

This Notice of Funding Opportunity (NOFO) is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary clinical trial.

Under this NOFO applicants are permitted to propose a research experience in a clinical trial led by a mentor or co-mentor. Those proposing a clinical trial or an ancillary clinical trial as lead investigator, should apply to the companion NOFO (PA-24-192).

Key Dates

| Category | Date(s)