PAR-25-100
Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R34 Clinical Trial Optional)
Summary
PAR-25-100: Pilot Health Services and Economic Research on Substance Use Disorder Treatment
Research Focus
This funding opportunity supports pilot and preliminary research to prepare for larger-scale services research effectiveness trials testing interventions, practices, and policies that optimize access to, quality, effectiveness, affordability, and utilization of tobacco or substance use disorder (SUD) treatments and services for comorbid medical and mental conditions. The National Institute on Drug Abuse (NIDA) Services Research Branch seeks research using rigorous methodologies across provider, organizational, system, and payer levels to advance sustained recovery from addiction and reduce SUD-related harms. Pilot studies should test key components of research methods—including trial design, study protocols, site recruitment, randomization procedures, data collection feasibility, and intervention delivery—that will inform subsequent larger R01-level trials. The program emphasizes implementation science, hybrid implementation/effectiveness trials, and dissemination research to accelerate translation of findings into practice, with particular attention to health disparities, patient engagement, scalability, sustainability, and stakeholder involvement.
At a Glance
- Who can apply: Eligible domestic and foreign institutions; specific eligibility details not stated in excerpt
- Funding & project length: Up to $450,000 direct costs over 3 years (max $225,000 per year)
- Award mechanism: R34 Planning Grant
- Key dates: Open January 16, 2025; multiple submission deadlines through May 8, 2027; earliest start December 2025
- Best fit for: Health services researchers, implementation scientists, and addiction medicine specialists studying SUD/tobacco treatment delivery, care integration, stigma reduction, social determinants, technology-enabled interventions, and transitions of care across diverse settings (treatment facilities, primary care, emergency departments, criminal legal, community settings)
Key Facts
Deadline
Fri, May 7, 2027
Posted
Fri, December 6, 2024
Award / Year (direct costs)
$225,000
Max Total
$450,000
Max Duration
3 years
Keywords
Research Areas
Gotchas (5)
Direct costs capped at $450,000 total over 3 years with annual maximum of $225,000 per year - applicants must structure budgets accordingly
98%
Source Text
“Direct costs are limited to $450,000 over the 3-year project period, with no more than $225,000 in direct costs allowed in any single year.”
Applications involving alcohol alone as a substance of use are explicitly not responsive and will not be reviewed
95%
Source Text
“Applications that involve alcohol alone as a substance of use Special Considerations”
Project period is strictly limited to maximum of 3 years with no flexibility
98%
Source Text
“The total project period for an application submitted may not exceed three years.”
Applications must follow program-specific instructions that deviate from the Application Guide, with strict enforcement and potential for delay or non-acceptance
92%
Source Text
“It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide, except where instructed to do otherwise (in this NOFO or in a Notice from NIH Guide for Grants and Contracts). Conformance to all requirements (both in the Application Guide and the NOFO) is required and strictly enforced. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do n”
FOA was recently updated (March 31, 2025) to align with agency priorities and applicants are instructed to carefully reread the full document and make adjustments - suggests material changes from prio
85%
Source Text
“This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.”