RFA-DK-26-313: AMP CMD Knowledge Portal Continuation

Research Focus

This funding opportunity supports continuation of the Accelerating Medicines Partnership (AMP) in Common Metabolic Diseases (CMD) Knowledge Portal, a curated web-based resource integrating genomic, epigenomic, and multi-omics data to advance understanding of common metabolic diseases including obesity, type 2 diabetes, cardiovascular disease, metabolic liver disease, and chronic kidney disease. The portal aggregates publicly available datasets and analytical tools to identify causal genetic variants, effector transcripts, and disease-driving molecular networks across these interconnected conditions. Over the next five years, the awardee will expand datasets and traits, integrate additional -omics data types, deploy new analytical and visualization tools, and develop a sustainability framework. The knowledge base serves the broad biomedical research community by enabling identification of candidate biomarkers, therapeutic targets, and disease sub-types relevant to precision medicine and drug discovery.

At a Glance

• Who can apply: Broad Institute, Inc. only (single-source, non-competitive award to current awardee)
• Funding & project length: Amount not stated; 5-year continuation period
• Award mechanism: U01 Research Project (Cooperative Agreement); clinical trials not allowed
• Key dates: Applications due March 6, 2026; scientific merit review July 2026; advisory council review October 2026; earliest start December 2026
• Best fit for: Biomedical informatics, genomics, and metabolic disease research; requires expertise in data curation, harmonization, multi-omics integration, and web portal development