PAS-25-073
Priority HIV/AIDS Research within the Mission of NIDDK (R01 Clinical Trial Optional)
Summary
PAS-25-073: Priority HIV/AIDS Research within the Mission of NIDDK
Research Focus
This funding opportunity targets HIV/AIDS research addressing systemic complications affecting organ systems within the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) mission. Research priorities include HIV-related comorbidities, co-infections, and complications (CCCs) such as HIV-associated enteropathy, gastrointestinal homeostasis loss, noncommunicable liver diseases, viral hepatitis co-infection, kidney and hematologic diseases, and obesity and diabetes. The program seeks mechanistic interrogation of pathophysiological pathways whereby HIV or antiretroviral therapy (ART) contributes to these conditions, as well as characterization of HIV reservoirs in NIDDK-relevant tissues including the gastrointestinal mucosa, male genital tract, kidney, and adipose tissue. Research on gastrointestinal and penile microbiomes, mucosal immunology, and the impact of health-impeding social determinants of health (SDoH) on CCCs and viral reservoir dynamics is encouraged. Basic, translational, and clinical research on biological, physiological, environmental, psychological, behavioral, and social processes are all in scope.
At a Glance
- Who can apply: U.S. institutions and organizations eligible for NIH funding; clinical trials optional
- Funding & project length: Not stated (consult R01 standard amounts); multiple rolling submission cycles through November 2027
- Award mechanism: R01 Research Project Grant
- Key dates: Open April 8, 2025; rolling deadlines (May 7, 2025 onward); earliest start December 2025
- Best fit for: Researchers studying HIV pathogenesis, organ-system complications, and viral reservoirs in metabolic, gastrointestinal, kidney, and endocrine tissues; mechanistic and implementation science approaches
Key Facts
Deadline
Fri, November 5, 2027
Posted
Wed, January 8, 2025
Award / Year (direct costs)
$250,000
Max Total
$1,250,000
Max Duration
5 years
Keywords
Research Areas
Gotchas (3)
The NOFO emphasizes that applicants must contact NIDDK staff early to confirm whether their proposed project falls within NIDDK's mission and goals. Projects outside the mission scope will be administ
90%
Source Text
“Applicants are strongly encouraged to contact NIDDK staff as soon as possible in the development of the application, so that NIDDK staff can help the applicant understand whether the proposed project is within the goals and mission of the Institute... Non-responsive applications will be administratively withdrawn without review and not considered for this NOFO.”
The NOFO emphasizes that research must be within NIDDK's mission, which is narrowly defined by organ systems (gastrointestinal, liver, pancreatic, kidney, urologic, hematologic, endocrine, metabolic,
95%
Source Text
“Projects with a primary focus on interrogating HIV reservoirs in tissues outside of the mission of NIDDK. Projects primarily focused on CCCs affecting organs, tissues, or processes outside of the mission of NIDDK... Non-responsive applications will be administratively withdrawn without review and not considered for this NOFO.”
Notice NOT-OD-26-029 (January 28, 2026) removed AIDS application due dates from this NOFO, but the table still lists multiple AIDS due dates through 2027, creating ambiguity about which deadlines are
95%
Source Text
“January 28, 2026 - NIH Removing AIDS Application Due Dates from NOFOs. See Notice NOT-OD-26-029. [followed by table with multiple AIDS due dates: May 07, 2025; September 07, 2025; January 07, 2026; May 07, 2026; June 05, 2026 / July 05, 2026; October 05, 2026 / November 05, 2026; February 05, 2027 / March 05, 2027; June 05, 2027 / July 05, 2027; October 05, 2027 / November 05, 2027]”