PAR-24-174
Global Infectious Disease Research Training Program (D43 Clinical Trial Optional)
Summary
Global Infectious Disease Research Training Program (D43 Clinical Trial Optional)
Research Focus & Contribution
This program funds joint training partnerships between low- and middle-income country (LMIC) institutions and U.S. research organizations to build sustainable infectious disease research capacity in resource-limited settings. The program targets major endemic diseases (malaria, tuberculosis), life-threatening emerging infectious diseases, neglected tropical diseases, and infections associated with non-communicable disease conditions—but explicitly excludes HIV/AIDS research. Training encompasses basic science, epidemiology, clinical research, behavioral and social science, bioengineering, bioinformatics, biostatistics, vector biology, pathophysiology, diagnostics, therapeutics, implementation science, health services research, and clinical trials. Programs must combine didactic coursework, mentored research experience, and professional development to prepare LMIC scientists and health professionals for independent careers addressing priority infectious disease research needs in their countries. The intended outcome is demonstrable, sustainable enhancement of infectious disease research capacity at the LMIC institution—moving beyond individual trainee advancement to institutional capability building.
At a Glance
- Who can apply: Joint applications from LMIC and U.S. institutions; LMIC institutions with limited current research capacity are especially encouraged.
- Funding & project length: Not stated; see Section II for award amounts and duration details.
- Award mechanism: D43 International Research Training Grants; trainees may lead independent clinical trials, conduct ancillary clinical trials, or gain experience in trials led by others.
- Key dates: Letter of intent due 30 days before application deadline; rolling deadlines with earliest start date August 6, 2025 (subsequent cycles August 2026, 2027); expiration August 7, 2026.
- Best fit for: Researchers in infectious disease epidemiology, clinical medicine, public health, and laboratory science seeking to establish or strengthen training programs in endemic disease research in LMICs.
Key Facts
Deadline
Thu, August 6, 2026
Posted
Wed, April 17, 2024
Keywords
Research Areas
Gotchas (6)
Applications must focus on infectious diseases in LMICs, but HIV/AIDS research training is explicitly excluded; applicants interested in HIV must apply to a different Fogarty program instead.
95%
Source Text
“This program does not support HIV/AIDS research training. Applicants interested in HIV research training should apply to the Fogarty HIV Research Training Program funding opportunities”
Not all NIH ICs participate in this parent announcement; applicants must verify IC participation and review IC-specific requirements before submitting, or their application will not be considered.
98%
Source Text
“Not all NIH Institutes and Centers participate in Parent Announcements. Applicants should carefully note which ICs participate in this announcement and view their respective areas of research interest and requirements at the Table of IC-Specific Information, Requirements and Staff Contacts website. ICs that do not participate in this announcement will not consider applications for funding.”
A recent notice (NOT-TW-24-007, June 5, 2024) updated foreign eligibility criteria for this program, indicating material changes to who can apply; applicants must review this notice.
92%
Source Text
“June 5, 2024 - Notice of Change to Funding Opportunity - Update of Foreign Eligibility Criteria for Global Infectious Disease Research Training Program (D43 Clinical Trial Optional). See Notice NOT-TW-24-007”
The proposed institutional training program must be clearly distinct from other ongoing research training and career development programs at the LMIC institution; applicants must demonstrate this dist
85%
Source Text
“The proposed institutional infectious disease research training program may complement other ongoing research training and career development programs at the LMIC institution, but the proposed program must be clearly distinct from related programs.”
The FOA allows trainees to lead independent clinical trials, propose ancillary clinical trials, or gain experience in clinical trials led by others, but the exact scope and constraints for clinical tr
75%
Source Text
“This Notice of Funding Opportunity (NOFO) allows appointment of Trainees (D43) proposing to serve as the lead investigator of an independent clinical trial; or proposing a separate ancillary clinical trial; or proposing to gain research experience in a clinical trial led by another investigator, as part of their research and career development.”
The FOA was updated March 31, 2025 to align with agency priorities; applicants are explicitly instructed to carefully reread the full funding opportunity and make adjustments to applications prior to
85%
Source Text
“This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.”