PAR-25-317
Risk and Protective Factors of Family Health and Family Level Interventions (R01 Clinical Trial Optional)
Summary
PAR-25-317: Risk and Protective Factors of Family Health and Family Level Interventions
Research Focus
This R01 Clinical Trial Optional program supports research on family-level health and resilience among populations experiencing health disparities. The initiative seeks observational and intervention studies examining how family functioning, cohesion, and resilience influence health outcomes and behaviors across two or more family members. Research should investigate mechanisms linking family-level risk and protective factors—including biological pathways (epigenome, microbiome), behavioral patterns, socio-cultural determinants, and environmental stressors—to family health outcomes. Studies may examine family decision-making around healthcare access, coping during extreme stressors (incarceration, substance abuse, disaster, death), chronic disease prevention and self-management, maternal and neonatal health, cancer prevention and survivorship, or care of family members with complex medical needs. Multidisciplinary approaches incorporating social determinants of health measures, life course perspectives, and health information technology applications are encouraged. Community partnerships and involvement in research conceptualization are supported.
At a Glance
- Who can apply: Institutions with NIH-eligible investigators; research must focus on families from NIH-designated populations experiencing health disparities in the United States.
- Funding & project length: Not stated; standard R01 mechanisms apply.
- Award mechanism: R01 Research Project Grant (clinical trial optional).
- Key dates: Open January 5, 2025; multiple rolling due dates through May 8, 2027 (earliest start dates December 2025 onward).
- Best fit for: Biomedical, clinical, behavioral, social, or population scientists studying family health, resilience, or health disparities; approaches combining biological, behavioral, and environmental domains.
Key Facts
Deadline
Sat, May 8, 2027
Posted
Fri, December 13, 2024
Keywords
Research Areas
Gotchas (5)
Family definition requires families to include individuals from 'populations NIH recognizes as experiencing health disparities' - this is a substantive eligibility constraint that differs from typical
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Source Text
“Family: two or more individuals from populations NIH recognizes as experiencing health disparities. These families share enduring intimate social relationships that may be characterized by blood or legal ties, shared residence, economic cooperation within or across borders, shared responsibilities, and a sense of mutual or collective obligation.”
Projects must include 'family health measures (i.e., health outcome(s) or behavior(s) measures for 2 or more family members)' - this is a mandatory structural requirement that differs from typical R01
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Source Text
“Projects are expected to include family health measures (i.e., health outcome(s) or behavior(s) measures for 2 or more family members).”
Use of standardized Social Determinants of Health measures from PhenX Toolkit is 'required' for studies with primary data collection - this is a specific technical mandate that may not be obvious from
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Source Text
“Studies involving primary data collection with human participants are strongly encouraged to incorporate Social Determinants of Health measures from the Core and Specialty collections that are available in the PhenX Toolkit (www.phenxtoolkit.org). Use of these standardized measures for individual demographic factors is required.”
Animal model studies are explicitly not supported - this is a clear exclusion that differs from typical R01 mechanisms and could disqualify mechanistic studies using animal models.
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Source Text
“Studies using animal models will not be supported under this PAR.”
FOA was recently updated (March 31, 2025) to align with agency priorities; applicants must carefully reread entire document
90%
Source Text
“This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.”