RFA-ES-25-002
Environmental Health Sciences Core Centers Program (P30 Clinical Trials Optional)
Summary
Environmental Health Sciences Core Centers Program (P30)
Research Focus
The Environmental Health Sciences Core Centers Program funds interdisciplinary research infrastructure centers that advance understanding of how environmental exposures affect human health and disease. Centers serve as intellectual hubs bringing together investigators from multiple disciplines to tackle complex environmental health questions—including identification of environmental hazards, development of prevention strategies, and translation of research into public health applications. The program emphasizes community engagement and translational research as essential approaches, with centers expected to support both independently-funded investigator projects and collaborative work that would be less efficient or effective without shared facilities, services, and resources. Research should align with the 2025–2029 NIEHS Strategic Plan and address environmental exposures and health outcomes across diverse populations and settings.
At a Glance
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Who can apply: Higher education institutions, nonprofits, for-profit organizations, state/local/tribal governments, and federal agencies. Applicant institution must demonstrate four or more center members with combined grant funding of at least $3 million/year in direct costs (at least 50% from NIH); awards must have ≥1 year remaining at submission.
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Funding & project length: $850,000 direct costs/year (new applicants) or $1.0M/year (renewals); up to 4 years (new) or up to 5 years (renewal). NIEHS intends $6.0M total FY 2026 for up to 4 awards.
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Award mechanism: P30 Center Core Grant (multi-project structure).
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Key dates: Open February 18, 2025; applications due March 18, 2025 (and subsequent cycles April 20, 2025/2026/2027); earliest start April 2026. FOA expires April 21, 2027.
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Best fit for: Established research institutions with existing environmental health research portfolios seeking to create or renew a center providing shared cores (Community Engagement Core, Translational Research Support Core) and infrastructure to support multi-disciplinary teams addressing environmental exposures, occupational health, environmental justice, climate health, or related domains.
Key Facts
Deadline
Tue, April 20, 2027
Posted
Thu, November 14, 2024
Award / Year (direct costs)
$850,000
Max Total
$3,400,000
Max Duration
4 years
Keywords
Research Areas
Gotchas (5)
New or first-time applicants are limited to $850,000 Direct Costs per year, while Renewal applications can request up to $1.0M Direct Costs per year. This distinction is critical and could be missed i
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Source Text
“New or first-time applicants are limited to $850,000 Direct Costs per year. Renewal applications are limited to $1.0M Direct Costs per year.”
Applicant institution must demonstrate that four or more Center members have combined grant funding of at least $3 million per year in direct costs, with at least 50% from NIH sources. This is a subst
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Source Text
“To be eligible for an EHSCC award, the applicant institution must demonstrate that four or more Center members have combined grant funding of at least $3 million per year in direct costs. At the time of submission of an application, the qualifying awards must have at least 1 full active year remaining. These projects must be Environmental Health Sciences focused, related to the NIEHS Mission and 2025-2029 NIEHS Strategic Plan, and address environmental exposures and health. These may be a mix of”
Specific grant mechanisms are explicitly listed as counting toward the $3M eligibility threshold, while T-awards, U45, Conference awards, and grants in extension periods or supplements explicitly do N
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“Examples of NIH peer-reviewed mechanisms that may be included for determining eligibility: DP1, DP2, R00, R01, R03, R15, R21, R24, R25, R33, R35, R37, R41, R42, R43, R44, P01, P20, P30s other than the EHSCC, P42, P50, SC1, SC2, U01, U10, U19, U24, U54, U56, UH2, UH3, UG3, K and F series awards. T-awards, U45, and Conference awards (R13, U13) do not count towards this requirement. Furthermore, grants and cooperative agreements in extension periods, either with or without additional funds, as well”
New or first-time applicants may apply for up to 4 years of support, while Renewal applications may request up to 5 years of support. Project period length differs by application type and could be ove
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“New or first-time applicants may apply for up to 4 years of support. Renewal application may request up to 5 years of support.”
The NOFO was updated on March 31, 2025 to align with agency priorities, and the expiration date was changed from January 30, 2027 to April 21, 2027 per NOT-ES-25-006. Applicants must carefully reread
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“This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission. Expiration Date New Date April 21, 2027 per NOT-ES-25-006 (Prior Date January 30, 2027).”