PAR-25-342
Interventions on Health and Healthcare Disparities on Non-Communicable and Chronic Diseases in Latin America: Improving Health Outcomes Across the Hemisphere (R01 - Clinical Trial Required)
Summary
PAR-25-342: Interventions on Health and Healthcare Disparities in Non-Communicable and Chronic Diseases in Latin America
Research Focus
This program supports clinical trials and intervention research addressing health disparities in non-communicable and chronic diseases (NCDs) affecting Latin America and U.S. Hispanic/Latino populations. The funder seeks innovative, team-based research on multicomponent or multilevel interventions—including community-based, health system-based, and pragmatic clinical trial designs—that improve prevention, diagnosis, treatment, and control of priority NCDs: diabetes, cardiovascular and cerebrovascular disease, hypertension, cancer, chronic kidney disease, chronic lung disease, dementia, and mental health conditions. Research on interpersonal violence and suicide is also of interest. Studies should identify and overcome barriers to healthcare access, utilization, and retention across fragmented healthcare systems, and test strategies to expand evidence-based prevention and care into community settings. The program emphasizes U.S.–Latin America collaborations that uncover mechanisms underlying documented health disparities and inform hemisphere-wide implementation of effective interventions.
At a Glance
- Who can apply: U.S. institutions and international partners collaborating on research in Latin America or with U.S. Hispanic/Latino populations; clinical trial required.
- Funding & project length: Not stated; standard R01 mechanisms apply.
- Award mechanism: R01 Research Project Grant (clinical trial required).
- Key dates: Applications due June 5, 2025 (earliest); February 5, 2026 and June 5, 2026 for subsequent cycles; earliest start April 2026.
- Best fit for: Epidemiologists, health services researchers, implementation scientists, and clinicians designing multicomponent interventions for chronic disease prevention/management in Hispanic/Latino or Latin American populations using quasi-experimental or randomized trial designs.
Key Facts
Deadline
Fri, May 7, 2027
Posted
Mon, January 13, 2025
Award / Year (direct costs)
$250,000
Max Total
$1,250,000
Max Duration
5 years
Keywords
Research Areas
Gotchas (5)
Clinical trial is required for all applications to this funding opportunity
95%
Source Text
“Interventions on Health and Healthcare Disparities on Non-Communicable and Chronic Diseases in Latin America: Improving Health Outcomes Across the Hemisphere (R01 - Clinical Trial Required)”
Research must include U.S.-Latin America collaboration - the NOFO emphasizes that research should involve 'bold and strategic U.S. and Latin America collaborations' and cannot be conducted solely in t
90%
Source Text
“Therefore, the overarching goal of this NOFO is to support innovative and collaborative research... bold and strategic U.S. and Latin America collaborations have strong potential to improve health outcomes... such research could inform current and future interventions... across the hemisphere. Furthermore, such research could inform current and future interventions to promote timely prevention, diagnosis and care of persons with NCDs more effectively across the hemisphere.”
Research must focus on specific NCDs with highest disease burden - obesity, diabetes, cardiovascular/cerebrovascular diseases, hypertension, hypercholesterolemia, cancer, chronic lung disease, chronic
95%
Source Text
“Those NCDs include obesity, diabetes and related complications, cardiovascular and cerebrovascular diseases, hypertension, hypercholesterolemia/dyslipidemia, cancer, chronic lung disease (including asthma), chronic kidney disease, osteoarthritis, as well as chronic liver disease and cirrhosis. In addition, sleep disordered breathing, cognitive impairment and dementia, and mental and behavioral health conditions have been increasingly studied in Hispanic/Latino persons in the U.S., and throughout”
Geographic scope is restricted to Latin America and U.S. Hispanic/Latino populations - research must involve Latin America or target U.S. Hispanic/Latino communities
95%
Source Text
“The purpose of this Notice of Funding Opportunity (NOFO) is to support innovative and interdisciplinary team research focused on clinical, health services, and/or community-based interventions that address health and healthcare disparities related to non-communicable and chronic diseases (NCDs) with the highest disease burden and mortality in Latin America and among U.S. Hispanics/Latinos.”
Interventions must be multicomponent or multilevel in nature - single-component interventions may not meet the scope
85%
Source Text
“This NOFO will support research on interventions (especially multicomponent or multilevel interventions), encompassing community-based and health system-based interventions, quasi-experimental studies, and clinical trials (including cluster-randomized trials, pragmatic trials), and other research designs that address the health and healthcare disparities in primary prevention, and/or awareness, effective treatment, and control of NCDs across the region.”