PAR-25-216
Career Transition Award for NINDS Intramural Clinician-Scientists (K22 Clinical Trial Required)
Summary
Career Transition Award for NINDS Intramural Clinician-Scientists (K22 Clinical Trial Required)
Research Focus & Contribution
This award supports the transition of NINDS intramural neurologists and neurosurgeons to independent academic faculty positions conducting neuroscience research. The program targets clinician-scientists who will lead their own clinical trials—either independent trials, feasibility studies, or ancillary studies—as the centerpiece of their research and career development. Applicants must develop a comprehensive career development plan addressing grant writing, experimental design, statistical methodology, and research rigor, alongside a well-conceived research project investigating a significant scientific problem within the NINDS mission (basic neuroscience, disease mechanisms, prevention, diagnosis, treatment, drug development, or neural devices). The research should be designed to transition from the NIH intramural phase to an extramural academic institution, with a significant component belonging to the candidate to ensure independent pursuit at their future institution.
At a Glance
- Who can apply: Licensed neurologists or neurosurgeons in the NINDS intramural program within 4 years of residency or clinical fellowship completion; applicants must propose to lead an independent clinical trial, feasibility study, or ancillary clinical trial.
- Funding & project length: Up to $125,000 per year toward salary (extramural phase); 5-year total award (up to 2 years intramural, 3+ years extramural); intramural phase includes $25,000 per year for research career development costs.
- Award / mechanism: K22 Career Transition Award (mentored grant).
- Key dates: Applications open January 12, 2025; earliest submission February 12, 2025; earliest start date December 2025 (varies by cycle through October 2027).
- Best fit for: Neurologists and neurosurgeons transitioning from NIH intramural positions to academic faculty roles; requires clinical trial leadership and mentored career development in neuroscience research.
Key Facts
Deadline
Fri, November 12, 2027
Posted
Mon, December 2, 2024
Award / Year (direct costs)
$150,000
Max Total
$750,000
Max Duration
5 years
Keywords
Research Areas
Gotchas (7)
By the end of the 4th year of the K22 award, recipients MUST submit an NIH R01, DP1, or R21 application as PD/PI to obtain the 5th year of K22 funding. Failure to submit this application will result i
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Source Text
“In order to obtain the 5th year of K22 funding, recipients must work with their institutions to submit an NIH R01, DP1 or R21 application, as PD/PI, by the end of the 4th year of the K22 award.”
This K22 is ONLY for applicants planning to lead an independent clinical trial, clinical trial feasibility study, or ancillary clinical trial. Applicants not planning an independent clinical trial or
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“This Notice of Funding Opportunity (NOFO) is designed specifically for applicants proposing to serve as the lead investigator of an independent clinical trial, a clinical trial feasibility study, or a separate ancillary study to an existing trial, as part of their research and career development. Applicants not planning an independent clinical trial, or proposing to gain research experience in a clinical trial led by another investigator, must apply to companion NOFO (PAR-25-215).”
Applicants MUST be licensed neurologists or neurosurgeons in the NINDS intramural program and within 4 years of completion of residency or clinical fellowship. This is a highly specific eligibility ga
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Source Text
“This funding opportunity is available to licensed neurologists and neurosurgeons in the NINDS intramural program who are within 4 years of completion of residency or clinical fellowship.”
The extramural phase requires a faculty position with minimum 9 person-months (75% effort) for neurologists OR 6 person-months (50% effort) for neurosurgeons, entirely dedicated to research. This is a
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“In order to transition to the extramural phase, recipients must obtain a faculty position at an academic institution that will provide a minimum of 9 person-months (75% of full-time professional effort) to neurologists or 6 person-months (50% full time professional effort) for neurosurgeons that is entirely dedicated to research.”
The extramural position must be either tenure-track or an equivalent, secure faculty position with strong institutional commitment. This is a specific requirement that may disqualify non-traditional o
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“This extramural position should either be a tenure-track position or an equivalent, secure faculty position, which includes a strong institutional commitment that will facilitate progress towards a successful dual career as clinician and research scientist.”
The extramural institution must provide access to resources and appropriate mentor(s) needed for completion of the K22 project and development of a strong R01/equivalent application. This is a require
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“the extramural institution must provide access to the resources, and have appropriate mentor(s), needed for completion of the K22 award research project and development of a strong application for an NIH R01 or equivalent award.”
During extramural support years, NINDS will contribute up to $125,000 per year toward the salary of the career award recipient. This is a specific salary cap that may be insufficient at some instituti
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Source Text
“During the extramural support years, NINDS will contribute up to $125,000 per year toward the salary of the career award recipient.”